According to Medical Xpress (This article and its images were originally posted on Medical Xpress September 12, 2018 at 10:01AM.)
(Cover Image)
Dispersed mitochondria (green, left) aggregated when Arf6 was disrupted (right) in a cancer cell, leading to excessive production of reactive oxygen species. Credit: Onodera Y., et al., Nature Communications, July 11, 2018
Targeting a pathway that controls the movement of mitochondria, the powerhouses of all cells, could reduce cancer invasiveness and resistance to radiotherapy.
A team of Hokkaido University scientists studied the molecules involved in mitochondrial movements within highly invasive breast cancer cells. They identified a pathway that ultimately leads to the dispersion of these energy-generating organelles towards the cells’ periphery, increasing cancer invasiveness.
When this pathway was blocked, mitochondria aggregated within the cell’s center, where they started overproducing and leaking reactive oxygen species (ROS)—unstable oxygen-containing molecules. ROS is known to enhance cancer invasiveness but in excessive amounts, it can lead to cancer cell death.
Got any news, tips or want to contact us directly? Feel free to email us: esistme@gmail.com.
To see more posts like these; please subscribe to our newsletter. By entering a valid email, you’ll receive top trending reports delivered to your inbox.
__
This article and its images were originally posted on [Medical Xpress] September 12, 2018 at 10:01AM. All credit to both the author and Medical Xpress | ESIST.T>G>S Recommended Articles Of The Day.
Donations are appreciated and go directly to supporting ESIST.Tech. Thank you in advance for helping us to continue to be a part of your online entertainment!
Thank you in advance for helping us to continue to be a part of your online entertainment!
ESIST 